| Expression pattern: |
UP |
| Associated gene: |
PEG10, paternally expressed 10, E2F3, Ago2 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
promotes proliferation, migration, invasion and xenograft tumor growth; inhibits apoptosis; promotes malignant behaviors of RB cells |
| Molecular mechanism: |
circ_0075804 functions as a cytoplasmic ceRNA/molecular sponge for miR-138-5p, thereby up-regulating PEG10 expression in RB cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
potential therapeutic target for RB |
| Description: |
circ_0075804 is up-regulated in retinoblastoma tissues and cell lines and acts as an oncogenic circRNA. It promotes RB cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0075804 sponges miR-138-5p to increase PEG10 expression, forming a circ_0075804/miR-138-5p/PEG10 regulatory axis with potential therapeutic relevance. |
| Confidence score: |
0.8443 |