| Expression pattern: |
DN |
| Associated gene: |
G3BP2, SRC, FAK |
| Associated microRNA: |
miR-1178-3p |
| Biological function: |
inhibits proliferation, migration and invasion; suppresses tumor growth and lymphatic metastasis |
| Molecular mechanism: |
circFNDC3B acts as a miR-1178-3p sponge to suppress G3BP2, thereby inhibiting downstream SRC/FAK signaling |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); SRC/FAK signaling (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circFNDC3B was correlated with pathological T stage, grade, lymphatic invasion and patients’ overall survival rate; low circFNDC3B expression exhibited poorer survival |
| Description: |
circFNDC3B (hsa_circ_0006156), derived from FNDC3B, is down-regulated in bladder cancer and acts as a tumor suppressor. It sponges miR-1178-3p to reduce G3BP2 and inactivate SRC/FAK signaling, thereby inhibiting proliferation, migration/invasion, tumor growth and lymphatic metastasis; low circFNDC3B is associated with poorer overall survival. |
| Confidence score: |
0.8837 |