| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-770-5p, hsa-miR-4712-5p, hsa-miR-4436b-5p, hsa-miR-1286, hsa-miR-6839-5p |
| Biological function: |
inhibits cell proliferation; promotes apoptosis |
| Molecular mechanism: |
Bioinformatics prediction suggested potential miRNA targeting (miRNA sponge hypothesis), but exact mechanism not determined. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
Potential noninvasive diagnostic biomarker for LA (AUC 0.830; sensitivity 60%; specificity 96.7%). |
| Description: |
circRNA6783 is up-regulated in lung adenocarcinoma, detectable in peripheral whole blood and LA cells. Overexpression in NCI-H1975 inhibits proliferation and increases apoptosis, suggesting potential as a noninvasive diagnostic biomarker; the molecular mechanism is not experimentally defined, with only predicted miRNA interactions. |
| Confidence score: |
0.6304 |