| Expression pattern: |
UP |
| Associated gene: |
QKI, EGFR, BCL2L1, PTPN11 |
| Associated microRNA: |
miR-1236-3p, miR-129-5p, miR-141-5p, miR-205-5p, miR-29a-5p, miR-942-5p |
| Biological function: |
Potential noninvasive diagnostic biomarker for breast cancer; may participate in a circRNA-miRNA-mRNA regulatory network involved in cancer development and progression. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network based on miRanda, MirTarget, STRING, Cytoscape and KEGG pathway analysis. |
| Biological pathway or process: |
ceRNA regulation (other); autophagy (other); NF-kappaB (other); JAK/STAT (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0001531 had diagnostic potential for breast cancer, with AUC 0.8258 in the discovery cohort, 0.9094 in the validation cohort and 0.8595 in the combined cohort. |
| Description: |
circ_0001531 was significantly up-regulated in whole blood from breast cancer patients and showed diagnostic value in ROC analyses. The study suggests circ_0001531 may act as part of a predicted circRNA-miRNA-mRNA network and may contribute to breast cancer-related regulatory processes, but functional mechanisms were not experimentally validated. |
| Confidence score: |
0.459 |