circRNA basic information
circBase ID: hsa_circ_0016760
Name: hsa_circ_SNAP47
Synonym: circ_0016760
Host Gene: -
Genomic location(hg19): chr1:227935392-227947186:+
Genomic location(hg38): chr1:227747691-227759485:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; neighboring normal tissues; tumor tissues
Cell lines:

A549; H1299; H1975; 16HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ZBTB7A
Associated microRNA: miR-577
Biological function: promotes colony formation, migration, invasion, glycolysis (ECAR) and tumor growth in NSCLC; circ_0016760 silencing suppresses these phenotypes
Molecular mechanism: ceRNA mechanism: circ_0016760 sponges miR-577 to regulate ZBTB7A expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot
Clinical significance:

-
Description:

circ_0016760 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC malignant phenotypes (colony formation, migration, invasion, glycolytic activity/ECAR) and tumor growth by acting as a ceRNA that sponges miR-577, thereby increasing ZBTB7A expression.
Confidence score:

0.7244
Other information
Title:

Circular RNA Circ_0016760 Modulates Non-Small-Cell Lung Cancer Growth Through the miR-577/ZBTB7A Axis.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32753969
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -