| Expression pattern: |
DN |
| Associated gene: |
UNKL |
| Associated microRNA: |
hsa-miR-6830-3p |
| Biological function: |
Potential diagnostic biomarker for CRC (high diagnostic efficiency by ROC); suggested involvement in CRC pathogenesis. |
| Molecular mechanism: |
Predicted ceRNA network and proposed core axis hsa_circRNA_071106-hsa-miR-6830-3p-UNKL (bioinformatics prediction). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic marker for CRC (ROC AUC = 0.9642). |
| Description: |
hsa_circRNA_071106 (host gene ARHGAP10) is significantly down-regulated in CRC tissues and shows high diagnostic value (AUC 0.9642). The paper proposes a predicted ceRNA axis hsa_circRNA_071106-hsa-miR-6830-3p-UNKL based on bioinformatics/TCGA hub gene screening, without direct mechanistic validation. |
| Confidence score: |
0.5963 |