circRNA basic information
circBase ID: hsa_circ_0072389
Name: hsa_circ_HMGCS1
Synonym: circHMGCS1
Host Gene: HMGCS1
Genomic location(hg19): chr5:43294157-43299077:-
Genomic location(hg38): chr5:43294055-43298975:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired normal tissues; liver cancer tissues; normal tissues; tumor tissues
Cell lines:

SMMC-7721
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AURKA, KIF5B
Associated microRNA: miR-581, miR-892a
Biological function: may play a vital role in HCC progression
Molecular mechanism: ceRNA mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

novel biomarkers in the detection of HCC; potentially valuable diagnostic biomarkers for HCC treatment
Description:

hsa_circ_0072389 (circHMGCS1) is up-regulated in HCC (validated by qPCR in SMMC-7721) and is proposed to drive HCC progression via ceRNA axes circHMGCS1/miR-581/AURKA and circHMGCS1/miR-892a/KIF5B. It is suggested as a potential biomarker for HCC detection.
Confidence score:

0.2465
Other information
Title:

Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.

Journal: Annals of translational medicine
Published: 2020
PubMed ID: 32355738
Study type:

combined biological and clinical study
Data availability: GSE94508; GSE97332; TCGA-LIHC; GTEx
Code availability: -