circRNA basic information
circBase ID: hsa_circ_0001324
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:107429298-107435696:+
Genomic location(hg38): chr3:107710451-107716849:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissue; distant normal tissue
Cell lines:

293T; AD293; HeLa; AGS; HGC-27; MKN-45
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PGC
Associated microRNA: hsa-let-7c
Biological function: May act as a ceRNA/miRNA sponge in GC and is associated with patient age (lower expression in ≥60 years old).
Molecular mechanism: ceRNA mechanism via binding (sponging) hsa-let-7c, affecting PGC down-regulation in GC tissue.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

Negatively correlated with patients' age; no significant association with overall survival.
Description:

hsa_circ_0001324 is down-regulated in gastric cancer tissue and binds hsa-let-7c. It is part of a proposed PGC-related ceRNA axis (hsa_circ_0001324-hsa-let-7c-PGC) that may contribute to PGC down-regulation, and its expression is associated with patient age.
Confidence score:

0.4685
Other information
Title:

Identification of PGC-related ncRNAs and their relationship with the clinicopathological features of Gastric Cancer.

Journal: Journal of Cancer
Published: 2021
PubMed ID: 34093839
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -