| Expression pattern: |
UP |
| Associated gene: |
LAD1 |
| Associated microRNA: |
miR-331 |
| Biological function: |
Promotes proliferation, migration and invasion of LUAD cells and promotes tumor growth. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-331 to upregulate LAD1 (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ-ANXA7 expression predicted poorer prognosis and circ-ANXA7 was an independent prognostic factor for LUAD. |
| Description: |
circ-ANXA7 is up-regulated in LUAD and promotes LUAD cell proliferation, migration and invasion and enhances tumor growth. Mechanistically, circ-ANXA7 sponges miR-331 to relieve repression of LAD1, forming a circ-ANXA7/miR-331/LAD1 axis. High circ-ANXA7 expression is associated with poorer overall survival and it serves as an independent prognostic factor. |
| Confidence score: |
0.8157 |