| Expression pattern: |
UP |
| Associated gene: |
PRDX3, STAT3, Ago2 |
| Associated microRNA: |
miR-567 |
| Biological function: |
Acts as an oncogene, promoting proliferation, migration and invasion, inhibiting apoptosis, enhancing chemosensitivity when silenced, and promoting RCC tumor growth in vivo. |
| Molecular mechanism: |
STAT3 induces circNUP98; circNUP98 functions as a miRNA sponge for miR-567 to upregulate PRDX3 via a ceRNA mechanism involving Ago2-RISC. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); chemoresistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
High expression of circNUP98 correlates with advanced tumour stage and poorer overall and disease-free survival in RCC patients; potential prognostic biomarker. |
| Description: |
circNUP98 is up-regulated in renal cell carcinoma and is associated with advanced stage and poor survival. It promotes RCC malignant phenotypes by sponging miR-567 to increase PRDX3, and its expression is induced by STAT3; silencing circNUP98 suppresses tumor growth and increases chemosensitivity. |
| Confidence score: |
0.8037 |