| Expression pattern: |
UP |
| Associated gene: |
COL1A1 |
| Associated microRNA: |
miR-193a-5p |
| Biological function: |
promotes colorectal cancer cell stemness and tumor-initiating ability |
| Molecular mechanism: |
acts as a ceRNA to sponge miR-193a-5p and upregulate COL1A1 in a miR-193a-5p-dependent manner |
| Biological pathway or process: |
stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Transfection; RNA Pull-Down; Luciferase Reporter Assay; CCK8; Western Blot; Colony Formation Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
correlated with TNM stage, depth of invasion, lymphatic metastasis and distant metastasis; high hsa_circ_0001806 level associated with lower overall survival |
| Description: |
hsa_circ_0001806 is upregulated in colorectal cancer and promotes cancer cell stemness and tumor-initiating ability. It functions as a ceRNA by sponging miR-193a-5p to relieve repression of COL1A1, forming a hsa_circ_0001806/miR-193a-5p/COL1A1 axis associated with advanced clinicopathologic features and poorer overall survival. |
| Confidence score: |
0.8625 |