circRNA basic information
circBase ID: hsa_circ_0078767
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:170615843-170639638:+
Genomic location(hg38): chr6:170306755-170330550:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues (ANT)
Cell lines:

BEAS-2B; A549; HCC827; H1299
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: GPX3
Associated microRNA: miR-665
Biological function: Inhibits proliferation, migration, invasion, glycolysis and tumor growth in NSCLC.
Molecular mechanism: Acts as a ceRNA sponge for miR-665 to regulate GPX3 expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Upregulation of circ_0078767 might be used as a treatment for NSCLC.
Description:

circ_0078767 is down-regulated in NSCLC tissues/cells and mainly localizes to the cytoplasm. Loss of circ_0078767 promotes NSCLC malignant phenotypes and glycolysis and accelerates xenograft tumor growth by sponging miR-665 to reduce GPX3 expression (circ_0078767/miR-665/GPX3 axis).
Confidence score:

0.6815
Other information
Title:

Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665.

Journal: International journal of genomics
Published: 2022
PubMed ID: 35340708
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -