| Expression pattern: |
UP |
| Associated gene: |
STAT1, AGO2 |
| Associated microRNA: |
miR-512-5p |
| Biological function: |
Promotes proliferation, migration and colony formation; promotes tumor growth in vivo (oncogenic role) in breast cancer. |
| Molecular mechanism: |
Acts as a cytoplasmic ceRNA/miRNA sponge for miR-512-5p, thereby relieving miR-512-5p-mediated repression and stabilizing STAT1 mRNA to promote breast cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; divergent primers PCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circRPPH1 level was associated with age and molecular subtypes in BC patients. |
| Description: |
circRPPH1 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It localizes mainly in the cytoplasm and promotes proliferation and migration by sponging miR-512-5p to increase STAT1 expression (circRPPH1/miR-512-5p/STAT1 axis). |
| Confidence score: |
0.8539 |