circRNA basic information
circBase ID: hsa_circ_0018289
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:46968580-46969453:-
Genomic location(hg38): chr10:46580164-46581035:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissue; adjacent normal tissue / matched non-tumor tissue
Cell lines:

HeLa; SiHa; CaSki; HT-3; C33A; HaCaT; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-497
Biological function: promotes proliferation, migration and invasion; promotes tumor growth/tumorigenesis
Molecular mechanism: acts as a miRNA sponge by directly binding miR-497
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

providing a potential biomarker for cervical cancer patients’ early detection
Description:

hsa_circ_0018289 is up-regulated in cervical cancer tissues and cell lines. Its knockdown suppresses cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth, and it directly binds miR-497, consistent with a miRNA-sponge role.
Confidence score:

0.721
Other information
Title:

Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis.

Journal: Oncotarget
Published: 2017
PubMed ID: 29156822
Study type:

combined biological and clinical study
Data availability: -
Code availability: -