circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain; heart; liver; lung; colon; stomach; primary hepatocellular carcinoma tissue; adjacent non-tumorous liver tissue; bladder urothelial carcinoma tissue; breast cancer tissue; colorectal cancer tissue; gastric cancer tissue; kidney clear cell carcinoma
Cell lines:

HEK-293T; HeLa; HCT-116; Huh-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AGO2, IL6R, DLX2
Associated microRNA: miR-124, miR-152, miR-193a, miR-29a, miR-29b, miR-338, miR-379, miR-584, miR-654
Biological function: promotes cell proliferation / cell growth
Molecular mechanism: miRNA sponge (ceRNA-like) binding multiple miRNAs, especially miR-124, thereby inhibiting miR-124 activity and affecting downstream targets (e.g., IL6R, DLX2).
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Northern Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Bioinformatics Analysis
Clinical significance:

-
Description:

circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2.
Confidence score:

0.8123
Other information
Title:

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.

Journal: Nature communications
Published: 2016
PubMed ID: 27050392
Study type:

combined biological and clinical study
Data availability: GSE77661
Code availability: -