| Expression pattern: |
DN |
| Associated gene: |
KAT6B |
| Associated microRNA: |
miR-452-5p |
| Biological function: |
Inhibits proliferation, cell cycle progression and autophagy, and promotes apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-452-5p to elevate KAT6B expression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (inhibits); autophagy (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circKIAA0907 has diagnostic and therapeutic value in GC; may have value in clinical screening, diagnosis, and prognosis. |
| Description: |
circKIAA0907 is downregulated in gastric cancer and mainly localizes to the cytoplasm. It suppresses GC cell proliferation, cell-cycle progression and autophagy while promoting apoptosis, and inhibits xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-452-5p to upregulate KAT6B. |
| Confidence score: |
0.8119 |