| Expression pattern: |
UP |
| Associated gene: |
MEK1, AGO2 |
| Associated microRNA: |
miR-489-3p |
| Biological function: |
promotes proliferation, invasion, metastasis and tumor growth in ccRCC |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) for miR-489-3p to modulate MEK1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; EdU Staining; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Upregulated circDHX33 in ccRCC patients significantly correlates with advanced TNM stage and metastasis. |
| Description: |
circDHX33 (hsa_circ_0000740), derived from DHX33, is up-regulated in ccRCC tissues and cell lines and correlates with advanced TNM stage and metastasis. Functionally, circDHX33 promotes ccRCC proliferation, invasion and in vivo tumor growth by acting as a cytoplasmic ceRNA that sponges miR-489-3p and thereby increases MEK1 expression. |
| Confidence score: |
0.8632 |