circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: SLC8A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson's disease
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

substantia nigra (SN); amygdala (AMG); medial temporalis gyrus (MTG)
Cell lines:

SH-SY5Y; HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Ago2, BMI1, SIRT1, AXIN1
Associated microRNA: miR-128
Biological function: associated with oxidative stress response and miR-128 target derepression in PD substantia nigra; potentially contributes to neuronal survival/aging-related regulation
Molecular mechanism: binds Ago2 and is predicted to bind miR-128 (7 sites); associated with increased miR-128 target mRNAs (BMI1, SIRT1, AXIN1), consistent with a ceRNA-like effect on miR-128 activity
Biological pathway or process:

oxidative phosphorylation (other); mitochondrial function (other); apoptosis (other); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); Transfection; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circSLC8A1 is up-regulated in substantia nigra of Parkinson’s disease donors and is inducible by oxidative stress (paraquat) in neuronal cells. It localizes to the cytoplasm, binds Ago2, and is linked to increased expression of miR-128 target genes (e.g., BMI1, SIRT1, AXIN1), consistent with modulation of miR-128 activity in PD-related oxidative stress context.
Confidence score:

0.717
Other information
Title:

A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress.

Journal: EMBO molecular medicine
Published: 2020
PubMed ID: 32715657
Study type:

combined biological and clinical study
Data availability: GSE133101
Code availability: -