| Expression pattern: |
DN |
| Associated gene: |
CDH1, Ago2 |
| Associated microRNA: |
miR-106a |
| Biological function: |
Suppresses proliferation, invasion and glycolysis, and promotes apoptosis of ovarian cancer cells; suppresses tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-106a, thereby up-regulating CDH1 expression |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); glycolysis (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Low circ-ITCH expression was associated with poor prognosis and lower 5-year survival rate; circ-ITCH was positively correlated with 5-year overall survival |
| Description: |
circ-ITCH is down-regulated in ovarian cancer and functions as a tumor suppressor. It sponges miR-106a to up-regulate CDH1, thereby inhibiting proliferation, invasion and glycolysis while promoting apoptosis, and it suppresses xenograft tumor growth. |
| Confidence score: |
0.8034 |