| Expression pattern: |
UP |
| Associated gene: |
MRP4 |
| Associated microRNA: |
miR-124-3p, miR-4524-5p |
| Biological function: |
Promotes MRP4 upregulation and may contribute to MRP4-related proliferation and multiple drug resistance in HCC. |
| Molecular mechanism: |
circHIPK3 acts as a competitive endogenous RNA (ceRNA) to sponge miR-124-3p and miR-4524-5p, thereby reducing free miRNAs and increasing MRP4 protein expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (other); drug resistance (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; circRIP; Transfection; Western Blot; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circHIPK3 is up-regulated in HCC tissues and functions as a ceRNA that sponges miR-124-3p and miR-4524-5p. By reducing the availability of these miRNAs, circHIPK3 increases MRP4 protein expression, which may relate to proliferation and multidrug resistance in HCC. |
| Confidence score: |
0.6427 |