| Expression pattern: |
UP |
| Associated gene: |
RIN1 |
| Associated microRNA: |
miR-761 |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion and EMT; inhibits apoptosis; promotes tumor growth and metastasis in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-761, thereby increasing RIN1 expression and promoting CRC growth and metastasis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
B
M
|
| Validation methods: |
Microarray; RT-qPCR; Northern Blot; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Associated with histology grade and liver metastasis; high expression predicts poor overall survival in CRC patients. |
| Description: |
hsa_circRNA_102209 is upregulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-761 to upregulate RIN1, thereby promoting proliferation, migration, invasion, EMT, and in vivo tumor growth/metastasis, and its high expression is associated with liver metastasis and poorer overall survival. |
| Confidence score: |
0.8427 |