circRNA basic information
circBase ID: hsa_circ_0008583
Name: -
Synonym: hsa_circ_0008583
Host Gene: -
Genomic location(hg19): chr3:196817782-196846401:-
Genomic location(hg38): chr3:197090911-197119530:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue (tumor); paracancerous tissue (non-tumor) / adjacent nontumor tissues
Cell lines:

LO2; Hep3B; Huh-7
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: METTL3
Associated microRNA: miR-1301-3p
Biological function: promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: hsa_circ_0008583 sponges miR-1301-3p to regulate METTL3
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0008583 is up-regulated in hepatocellular carcinoma tissues and cell lines. Functionally, it promotes HCC cell proliferation, migration and invasion and inhibits apoptosis, and its depletion suppresses xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-1301-3p to relieve repression of METTL3 (hsa_circ_0008583/miR-1301-3p/METTL3 axis).
Confidence score:

0.6521
Other information
Title:

Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway.

Journal: Bioengineered
Published: 2022
PubMed ID: 35258395
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author, upon reasonable request.
Code availability: -