circRNA basic information
circBase ID: hsa_circ_0049658
Name: hsa_circ_NFIX
Synonym: circNFIX
Host Gene: NFIX
Genomic location(hg19): chr19:13183860-13192669:+
Genomic location(hg38): chr19:13073046-13081855:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain tissues
Cell lines:

HA; T98; U251; SW1783; A172
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RPN2, Ago2
Associated microRNA: miR-378e
Biological function: promotes cell cycle progression, glycolysis, migration and invasion and inhibits apoptosis in glioma; promotes xenograft tumor growth
Molecular mechanism: ceRNA mechanism: circNFIX sponges miR-378e to positively regulate RPN2
Biological pathway or process:

cell cycle (promotes); glycolysis (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

high expression of circNFIX indicated poor outcomes of patients; associated with WHO stage and tumor size
Description:

circNFIX (hsa_circ_0049658), derived from NFIX, is up-regulated in glioma and its high expression correlates with poor patient survival. Functionally, circNFIX promotes glioma progression (cell cycle progression, glycolysis, migration/invasion, and tumor growth) by acting as a ceRNA that sponges miR-378e to upregulate RPN2.
Confidence score:

0.8436
Other information
Title:

CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.

Journal: Journal of experimental & clinical cancer research : CR
Published: 2019
PubMed ID: 31888753
Study type:

combined biological and clinical study
Data availability: Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.
Code availability: -