circRNA basic information
circBase ID: hsa_circ_0007915
Name: hsa_circ_IPO11
Synonym: hsa_circ_00007915
Host Gene: IPO11
Genomic location(hg19): chr5:61745753-61747760:+
Genomic location(hg38): chr5:62449926-62451933:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-106a
Biological function: circulating diagnostic biomarker candidate; distinguishes stage III vs stage IV CRC; highest expression in TME (bioinformatic single-cell visualization)
Molecular mechanism: tested correlation with miR-106a but no significant correlation
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Cohort Study; Bioinformatics Analysis
Clinical significance:

plasma level increased in CRC; ROC supports diagnostic value; can distinguish stage III vs stage IV
Description:

hsa_circ_0007915 is up-regulated in CRC plasma and has the best diagnostic performance among the tested circRNAs. It can differentiate stage III from stage IV CRC by ROC analysis. The study assessed a proposed interaction with miR-106a via correlation analysis but found no significant correlation.
Confidence score:

0.6023
Other information
Title:

New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.

Journal: International journal of molecular sciences
Published: 2021
PubMed ID: 34948079
Study type:

clinical study
Data availability: available on request from the corresponding author at e-mail: maria.radanova@mu-varna.bg
Code availability: -