| Expression pattern: |
UP |
| Associated gene: |
CDK2 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
promotes cervical cancer cell proliferation and adhesion; facilitates cervical cancer aggressiveness; inhibits apoptosis; affects cell cycle progression (cell cycle arrest upon silencing) |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ_0084927 sponges miR-1179 to relieve repression of CDK2 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; BrdU; Cell Cycle Assay; MTT; Western Blot |
| Clinical significance: |
- |
| Description: |
circ_0084927 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It mainly promotes malignant phenotypes (proliferation/adhesion and cell-cycle progression, and suppresses apoptosis) by sponging miR-1179, thereby releasing CDK2 expression in a circ_0084927/miR-1179/CDK2 ceRNA axis. |
| Confidence score: |
0.7893 |