| Expression pattern: |
UP |
| Associated gene: |
DDX5, AKT, p-AKT |
| Associated microRNA: |
miR-106a-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, and invasion; promotes viability; activates AKT phosphorylation. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-106a-5p to relieve repression of DDX5 mRNA, increasing DDX5 and p-AKT levels. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circEGFR expression was correlated with poor clinicopathological characteristics and poor prognosis; associated with overall survival and cumulative recurrence after surgery; may serve as a diagnostic marker and therapeutic target. |
| Description: |
circEGFR (hsa_circ_0080220) is up-regulated in colorectal cancer tissues and promotes CRC cell proliferation and invasion/migration in vitro. It functions as a ceRNA by sponging miR-106a-5p, derepressing DDX5 and increasing p-AKT, and higher circEGFR is associated with poorer prognosis and recurrence. |
| Confidence score: |
0.7113 |