| Expression pattern: |
UP |
| Associated gene: |
AFP |
| Associated microRNA: |
- |
| Biological function: |
Potential circulating biomarker/fingerprint to distinguish HCC from CH or healthy controls; decreases after hepatectomy suggesting tumor origin. |
| Molecular mechanism: |
Not established; diagnostic biomarker evaluation with ROC and risk score analysis. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Candidate circulating fingerprint/biomarker for distinguishing HCC from CH or healthy controls; combination with AFP improves diagnostic performance. |
| Description: |
circ_0140117 is up-regulated in plasma (and tumor tissue) of HBV-related HCC patients versus CH or healthy controls, and decreases after hepatectomy. It is a candidate circulating biomarker/fingerprint whose combination with AFP yields higher diagnostic sensitivity and specificity. |
| Confidence score: |
0.5963 |