| Expression pattern: |
UP |
| Associated gene: |
PTBP1, SFRS1, AGO2 |
| Associated microRNA: |
miR-1205 |
| Biological function: |
Promotes cervical cancer cell viability, proliferation, invasion, tumorigenesis and in vivo tumor growth; suppresses apoptosis. |
| Molecular mechanism: |
circIL21R acts as a ceRNA for miR-1205 to upregulate PTBP1; SFRS1 directly binds circIL21R to maintain its stability and upregulate its expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); mRNA stability (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis; Transfection; EdU Staining; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher circIL21R expression indicated shorter survival; circIL21R is a potential biomarker for the diagnosis and treatment of cervical cancer. |
| Description: |
circIL21R is up-regulated in cervical cancer and high expression is associated with shorter survival. It promotes cervical cancer cell proliferation, invasion and tumor growth by acting as a ceRNA for miR-1205 to increase PTBP1 expression, while SFRS1 binds circIL21R to maintain its stability. |
| Confidence score: |
0.8766 |