| Expression pattern: |
UP |
| Associated gene: |
DUSP2 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
Promotes HCC cell proliferation, migration, tumor growth and pulmonary metastasis; downregulation suppresses these malignant phenotypes. |
| Molecular mechanism: |
circ-EIF3I promotes DUSP2 expression by sponging miR-361-3p, thereby regulating HCC cell proliferation and migration. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Sanger Sequencing; RT-qPCR; FISH / smFISH; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
Potential predictive biomarker, diagnostic biomarker, and therapeutic target for HCC. |
| Description: |
circ-EIF3I (hsa_circ_0011385) is up-regulated in HCC cell lines and functions as an oncogenic circRNA. Silencing circ-EIF3I suppresses HCC proliferation, migration, xenograft tumor growth and pulmonary metastasis. Mechanistically, circ-EIF3I promotes DUSP2 expression by sponging miR-361-3p, forming a circ-EIF3I/miR-361-3p/DUSP2 regulatory axis. |
| Confidence score: |
0.7416 |