| Expression pattern: |
UP |
| Associated gene: |
COL1A1, COL4A1, CDK6 |
| Associated microRNA: |
miR-124, miR-29b |
| Biological function: |
Promotes GC cell proliferation; associated with aggressive characteristics (T stage; Ming’s classification). |
| Molecular mechanism: |
Negative regulation of miR-124 and miR-29b (ceRNA/miRNA sponge-based network) affecting downstream targets (e.g., COL1A1, COL4A1, CDK6) in cancer-related pathways. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Sanger Sequencing; Bioinformatics Analysis |
| Clinical significance: |
circHIPK3 expression is associated with T stage and Ming’s classification; proposed as a potential biomarker in histological classification of GC. |
| Description: |
circHIPK3 is up-regulated in gastric cancer and correlates with aggressive clinicopathological features (T stage and Ming’s classification). Functionally, it promotes GC cell proliferation and is linked to a circHIPK3-miR-124/miR-29b regulatory network affecting downstream targets such as COL1A1, COL4A1 and CDK6. |
| Confidence score: |
0.6102 |