circRNA basic information
circBase ID: hsa_circ_0041103
Name: hsa_circ_TCF25
Synonym: circTCF25
Host Gene: TCF25
Genomic location(hg19): chr16:89962397-89967202:+
Genomic location(hg38): chr16:89895989-89900794:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder carcinoma
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder carcinoma tissue; para-carcinoma tissue
Cell lines:

T24; EJ; Hela
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDK6, RAD51, BCL2, RUNX1T1, AXIN2, ITGA2, FGF2, WNT3A, CRKL, ARNT, HIF1A, CCNE1, VEGFA
Associated microRNA: miR-103a-3p, miR-107
Biological function: promotes proliferation and migration; promotes tumor growth and metastasis
Molecular mechanism: Acts as a miRNA sponge for miR-103a-3p/miR-107, relieving repression of CDK6 and other predicted targets.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); cell cycle (promotes); apoptosis (inhibits); PI3K/AKT/mTOR (other); Wnt/beta-catenin (other); VEGF/VEGFR (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Bioinformatics Analysis; Transfection; Western Blot; Wound Healing Assay; EdU Staining
Clinical significance:

circTCF25 might be a new promising marker for bladder cancer; potentially valuable diagnostic biomarker
Description:

circTCF25 is up-regulated in bladder carcinoma and promotes proliferation and migration. Mechanistically, it sequesters miR-103a-3p/miR-107, leading to increased CDK6 expression (and additional predicted oncogenic targets), supporting a ceRNA-like regulatory role and potential biomarker value.
Confidence score:

0.6528
Other information
Title:

Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.

Journal: Scientific reports
Published: 2016
PubMed ID: 27484176
Study type:

combined biological and clinical study
Data availability: -
Code availability: -