| Expression pattern: |
UP |
| Associated gene: |
AJUBA, MST1, LATS1, YAP |
| Associated microRNA: |
hsa‐miR‐1184 |
| Biological function: |
promotes proliferation, migration and invasion; promotes cell cycle progression; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism: hsa_circ_0128846 sponges miR-1184 to increase AJUBA expression and inactivate Hippo/YAP signaling |
| Biological pathway or process: |
Hippo/YAP (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
- |
| Description: |
hsa_circ_0128846 (circ_0128846) is up-regulated in colorectal cancer tissues and CRC cell lines. It promotes CRC proliferation, migration, invasion, cell cycle progression and tumor growth by sponging miR-1184, thereby increasing AJUBA and inactivating Hippo/YAP signaling. |
| Confidence score: |
0.7801 |