circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: circSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): chr4:144464661-144465125:+
Genomic location(hg38): chr4:143543508-143543972:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; adjacent nontumor tissue; plasma
Cell lines:

HepG2; HCCLM9; Hep3B; HCCLM3; MHCC97L; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: QKI
Associated microRNA: -
Biological function: promotes apoptosis; inhibits proliferation, migration, and invasion of HCC cells; tumor suppressor role in HCC
Molecular mechanism: not specified
Biological pathway or process:

apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; ROC Analysis
Clinical significance:

plasma hsa_circ_0001445 levels were lower in HCC patients than in healthy controls, cirrhosis or hepatitis B patients, and ROC curve analysis supported diagnostic value; combined with AFP improved diagnostic efficacy
Description:

hsa_circ_0001445 (circSMARCA5), derived from SMARCA5, is down-regulated in HCC tissues and in several HCC cell lines. Its overexpression promotes apoptosis and suppresses proliferation, migration and invasion, consistent with a tumor-suppressive role. Plasma hsa_circ_0001445 is reduced in HCC and shows diagnostic potential by ROC analysis, especially when combined with AFP.
Confidence score:

0.6148
Other information
Title:

The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker.

Journal: Disease markers
Published: 2018
PubMed ID: 29785229
Study type:

combined biological and clinical study
Data availability: -
Code availability: -