| Expression pattern: |
UP |
| Associated gene: |
PICALM, mRNAs |
| Associated microRNA: |
hsa-miR-33b-5p, hsa-miR-33a-5p, hsa-miR-148a-5p, hsa-miR-502-5p, hsa-miR-891b |
| Biological function: |
May be related to depression occurrence in T2DM, possibly via autophagy-related mechanisms (inferred through PICALM). |
| Molecular mechanism: |
May function as a miRNA sponge; associated with target gene PICALM and predicted pathways. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); thyroid hormone (other); Wnt/beta-catenin (other); EGFR (other); autophagy (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa-circRNA_100918 (linked to host/target gene PICALM) is up-regulated in whole blood of T2DM patients with depression and validated by RT-qPCR. The paper proposes it may act as a miRNA sponge in a predicted circRNA/miRNA/mRNA network and suggests relevance to autophagy-related mechanisms via PICALM, with KEGG implicating thyroid hormone, Wnt, ErbB and MAPK signaling. |
| Confidence score: |
0.5135 |