| Expression pattern: |
UP |
| Associated gene: |
GDF15 |
| Associated microRNA: |
miR-1233-3p |
| Biological function: |
Promotes GC cell proliferation, migration, invasion and colony formation (oncogenic role). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1233-3p to regulate downstream GDF15 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Tissue hsa-circ-0007766 has diagnostic value for GC (AUC 0.704; sensitivity 53.33%; specificity 83.33%). |
| Description: |
hsa-circ-0007766 is up-regulated in gastric carcinoma tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion, colony formation). Mechanistically, it functions as a ceRNA by sponging miR-1233-3p to increase GDF15 expression, and it shows potential diagnostic value by ROC analysis. |
| Confidence score: |
0.8562 |