| Expression pattern: |
UP |
| Associated gene: |
E2F1 |
| Associated microRNA: |
miR-29a-3p |
| Biological function: |
Promotes ovarian cancer progression by inducing EMT, enhancing cell viability, invasion/migration, colony formation, tumor growth and lung metastasis. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-29a-3p to upregulate E2F1, thereby inducing EMT in ovarian cancer cells. |
| Biological pathway or process: |
EMT (promotes); invasion (promotes); migration (promotes); proliferation (promotes); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Colony Formation Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis; In Vivo Animal Model; Survival Analysis; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
High circFGFR3 level is associated with lower survival rates and higher recurrence rates and may be a prognostic biomarker for OC patients. |
| Description: |
circFGFR3 is up-regulated in ovarian cancer tissues/cells and promotes OC progression by inducing EMT. It functions as a ceRNA by sponging miR-29a-3p to increase E2F1 expression, enhancing proliferation/viability, invasion/migration, and tumor growth/metastasis; high circFGFR3 is associated with poor prognosis and recurrence. |
| Confidence score: |
0.8198 |