circRNA basic information
circBase ID: hsa_circ_0007385
Name: -
Synonym: circular RNA_0007385
Host Gene: -
Genomic location(hg19): chr2:32142994-32157204:-
Genomic location(hg38): chr2:31917925-31932135:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small‐cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh‐frozen tumor specimens; fresh‐frozen adjacent specimens
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

High tumor hsa_circ_0007385 expression correlates with lymph node metastasis and higher TNM stage, and predicts worse DFS and OS; it independently predicts worse OS; ROC AUC 0.922 for distinguishing tumor from adjacent non-tumor tissue.
Description:

In resected NSCLC patient tissues, hsa_circ_0007385 is up-regulated in tumors versus adjacent non-tumor tissues and can distinguish tumors from controls. High tumor hsa_circ_0007385 expression associates with more advanced disease features (lymph node metastasis, higher TNM stage) and predicts worse DFS/OS, independently predicting worse OS.
Confidence score:

0.5918
Other information
Title:

Value of circular RNA 0007385 in disease monitoring and prognosis estimation in non-small-cell lung cancer patients.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32666646
Study type:

clinical study
Data availability: -
Code availability: -