| Expression pattern: |
UP |
| Associated gene: |
mRNAs |
| Associated microRNA: |
hsa-miR-145-5p |
| Biological function: |
potentially associated with inflammation/autoimmune pathogenesis in T1DM (in silico functional annotation); proposed as potential biomarker |
| Molecular mechanism: |
predicted miRNA sponge (sponging hsa-miR-145-5p) with downstream mRNA network (in silico) |
| Biological pathway or process: |
immune regulation (other); inflammation (other); Wnt/beta-catenin (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
potential diagnostic biomarker for T1DM |
| Description: |
hsa_circRNA_085129 is significantly up-regulated in plasma of new-onset T1DM patients (validated by qRT-PCR). It is predicted to sponge hsa-miR-145-5p and contribute to inflammation/immune-related regulatory networks implicated in T1DM, suggesting potential biomarker value. |
| Confidence score: |
0.5135 |