circRNA basic information
circBase ID: -
Name: hsa_circ_VCAN
Synonym: circVCAN
Host Gene: VCAN
Genomic location(hg19): chr5:82815168-82818128:.
Genomic location(hg38): chr5:83519349-83522309:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005229
MONDO name: bacterial infectious disease with sepsis
Disease details: sepsis
Disease DO ID:
 0040085
Disease MeSH ID:
 D016470
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; peripheral blood mononuclear cells (PBMCs); CD14+ monocytes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: The study reports increased abundance in monocytes and does not support a miRNA sponge role for the altered circRNAs.
Biological pathway or process:

Notch (other); ERK (other); proliferation (other); inflammation (other)
Detected method:
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR
Clinical significance:

-
Description:

circVCAN is significantly increased in CD14+ monocytes from sepsis patients secondary to CAP versus healthy controls based on RNA-seq. The study experimentally confirms circVCAN is a bona fide RNase R-resistant circular transcript in healthy human monocytes, but does not establish a specific miRNA-sponge mechanism or direct downstream targets.
Confidence score:

0.437
Other information
Title:

The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis.

Journal: Critical care (London, England)
Published: 2020
PubMed ID: 32660590
Study type:

combined biological and clinical study
Data availability: GSE136200
Code availability: -