| Expression pattern: |
UP |
| Associated gene: |
MMP2, Ago2 |
| Associated microRNA: |
miR-326, miR-330-5p |
| Biological function: |
facilitates NSCLC cell proliferation, migration and invasion/metastasis; inhibits apoptosis |
| Molecular mechanism: |
circ_0000517 acts as a miRNA sponge (ceRNA) for miR-326 and miR-330-5p to up-regulate MMP2 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Up-regulation of circ_0000517 is associated with advanced clinical stage, lymph node metastasis, and poor prognosis in NSCLC patients |
| Description: |
circ_0000517 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation and metastatic behaviors while inhibiting apoptosis by sponging miR-326 and miR-330-5p, thereby increasing MMP2 expression. |
| Confidence score: |
0.8632 |