circRNA basic information
circBase ID: -
Name: hsa_circ_NOX4
Synonym: hsa_circRNA_100933 / circRNA_100933
Host Gene: NOX4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006500
MONDO name: hemangioma
Disease details: hemangioma
Disease DO ID:
 255
Disease MeSH ID:
 D006391
Disease NCIt ID:
 C3085
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

IH tissue; adjacent skin tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: 100 target genes
Associated microRNA: miR-1298-3p, miR-892b, miR-2113, miR-137, miR-514a-5p
Biological function: May be involved in neovascularization-related biological processes in IH (e.g., epithelial cell migration, vasculature development, tissue migration).
Molecular mechanism: Predicted circRNA-miRNA-mRNA (ceRNA) network involving miRNA response elements (MREs) and target genes.
Biological pathway or process:

angiogenesis (other); migration (other); VEGF/VEGFR (other); EGFR (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_100933 is up-regulated in infantile hemangioma tissues and was validated by qRT-PCR. Bioinformatics prediction supports a circRNA-miRNA-mRNA regulatory network (with miR-1298-3p/miR-892b/miR-2113/miR-137/miR-514a-5p) potentially related to angiogenesis and vascular development processes.
Confidence score:

0.585
Other information
Title:

Circular RNA profile of infantile hemangioma by microarray analysis.

Journal: PloS one
Published: 2017
PubMed ID: 29095957
Study type:

combined biological and clinical study
Data availability: GSE93522; GSE78811
Code availability: -