| Expression pattern: |
UP |
| Associated gene: |
ITSN1, UBE3B, BCL2L2, ITSN1, EphB4 |
| Associated microRNA: |
hsa-miR-296-5p, hsa-miR-1226-5p, hsa-miR-6887-3p, hsa-miR-7106-3p, hsa-miR-6508-3p |
| Biological function: |
unknown |
| Molecular mechanism: |
Predicted to act as a miRNA sponge in a circRNA-miRNA-mRNA network (e.g., via miR-1226-5p targeting ITSN1). |
| Biological pathway or process: |
ceRNA regulation (other); RAS signaling (other); MAPK (other); inflammation (other); apoptosis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circRNA_001145 is significantly up-regulated in POCD patient serum and was included in the validated differentially expressed circRNAs. The study predicts it may function as a ceRNA by sponging miRNAs (e.g., miR-1226-5p) to influence target genes such as ITSN1 in a circRNA-miRNA-mRNA network relevant to POCD-related processes. |
| Confidence score: |
0.4761 |