circRNA basic information
circBase ID: hsa_circ_0000069
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:47745912-47748131:-
Genomic location(hg38): chr1:47280240-47282459:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; para-tumor tissues; adjacent normal tissues; tumor tissues; xenografts
Cell lines:

SiHa; C-4I; HeLa; C-33A; End1/E6E7
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TUSC3
Associated microRNA: miR-873-5p
Biological function: promotes proliferation, migration and invasion; promotes tumor growth in vivo
Molecular mechanism: Acts as a miRNA sponge for miR-873-5p to facilitate TUSC3 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Upregulated in CC tissues and associated with lymph node metastasis and lower survival of CC patients
Description:

hsa_circ_0000069 is up-regulated in cervical cancer and promotes proliferation, migration, invasion, and xenograft tumor growth. It functions as a ceRNA by sponging miR-873-5p, thereby increasing TUSC3 expression, and its high expression is associated with lymph node metastasis and poor overall survival.
Confidence score:

0.7855
Other information
Title:

CircRNA hsa_circRNA_0000069 promotes the proliferation, migration and invasion of cervical cancer through miR-873-5p/TUSC3 axis.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32655319
Study type:

combined biological and clinical study
Data availability: GSE102686
Code availability: -