| Expression pattern: |
DN |
| Associated gene: |
Lin28a, UBE2V1, UBC13, PTEN mRNA, QKI |
| Associated microRNA: |
- |
| Biological function: |
Inhibits bladder cancer invasion, migration, vasculogenic mimicry formation, and metastasis. |
| Molecular mechanism: |
Acts as a scaffold promoting UBE2V1/UBC13 binding to Lin28a to enhance ubiquitin/proteasome-dependent degradation of Lin28a, thereby increasing PTEN mRNA stability and suppressing PI3K/AKT pathway phosphorylation; its formation is promoted by QKI. |
| Biological pathway or process: |
PI3K/AKT/mTOR (inhibits); invasion (inhibits); migration (inhibits); metastasis (inhibits); angiogenesis (inhibits) |
| Detected method: |
Q
H
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis; Survival Analysis; RNA-seq |
| Clinical significance: |
High expression of hsa_circ_0000520 predicted better prognosis for bladder cancer patients. |
| Description: |
hsa_circ_0000520 is downregulated in bladder cancer and functions as a tumor suppressor by inhibiting invasion, migration, vasculogenic mimicry, and metastasis. It acts as a cytoplasmic scaffold to promote UBE2V1/UBC13-mediated ubiquitination and degradation of Lin28a, increasing PTEN mRNA stability and suppressing PI3K/AKT/mTOR signaling; its biogenesis is promoted by QKI. |
| Confidence score: |
0.8814 |