| Expression pattern: |
UP |
| Associated gene: |
FOXO3, ABCB1 |
| Associated microRNA: |
miR-605 |
| Biological function: |
Promotes HCC cell proliferation, cell cycle progression, tumor growth and oxaliplatin resistance; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-605 to regulate FOXO3, which transcriptionally activates ABCB1, promoting oxaliplatin resistance. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; ChIP / ChIP-seq; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circFBXO11 is up-regulated in HCC tissues and its overexpression is associated with poor prognosis and lower survival rate. |
| Description: |
circFBXO11 (hsa_circ_0001001), derived from FBXO11, is up-regulated in HCC and associated with poor prognosis. It promotes proliferation, cell-cycle progression, tumor growth, and oxaliplatin resistance by sponging miR-605 to enhance FOXO3, which transcriptionally activates ABCB1. |
| Confidence score: |
0.8632 |