| Expression pattern: |
UP |
| Associated gene: |
SLC7A11, p38, ERK |
| Associated microRNA: |
miR-143-3p |
| Biological function: |
CircPVT1 facilitates OSCC progression by promoting proliferation, migration, invasion, metastasis and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
CircPVT1 acts as a ceRNA sponge for miR-143-3p to upregulate SLC7A11 and activate the p38/ERK MAPK signaling pathway. |
| Biological pathway or process: |
MAPK (promotes); ERK (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircPVT1 may provide a new biomarker or therapeutic approach for OSCC treatment. |
| Description: |
CircPVT1 is upregulated in OSCC tissues and cells. It promotes OSCC proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-143-3p to increase SLC7A11 and activate the p38/ERK MAPK pathway. |
| Confidence score: |
0.7294 |