| Expression pattern: |
UP |
| Associated gene: |
ROCK1 |
| Associated microRNA: |
miR-182 |
| Biological function: |
Promotes migration and invasion, supports cell-cycle progression, and inhibits apoptosis in gastric cancer cells; circNRIP1 knockdown reverses these phenotypes. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-182 to derepress ROCK1. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Transfection; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
High expression of circNRIP1 indicated poor survival of patients. |
| Description: |
circNRIP1 is up-regulated in gastric cancer and higher levels are associated with worse overall survival. Functionally, circNRIP1 promotes migration and invasion and suppresses apoptosis by sponging miR-182, thereby derepressing ROCK1 expression (circNRIP1/miR-182/ROCK1 ceRNA axis). |
| Confidence score: |
0.7992 |