| Expression pattern: |
UP |
| Associated gene: |
E2F3, CXCL6 |
| Associated microRNA: |
miR-507, miR-515-5p |
| Biological function: |
promotes HCC cell growth, inhibits apoptosis, and promotes migration and invasion |
| Molecular mechanism: |
ceRNA mechanism: circ_0005394 sponges miR-507 and miR-515-5p to increase E2F3 and CXCL6 expression; rescue assays support miR-507/E2F3 and miR-515-5p/CXCL6 pathways |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High expression of circ_0005394 was associated with larger tumor size, more advanced TNM stages, and poorer overall survival; circ_0005394 was an independent prognostic predictor for HCC. |
| Description: |
circ_0005394 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation/viability, migration and invasion and suppresses apoptosis by sponging miR-507 and miR-515-5p to de-repress E2F3 and CXCL6 (miR-507/E2F3 and miR-515-5p/CXCL6 axes). High circ_0005394 expression predicts poorer overall survival and is an independent prognostic factor in an 82-patient cohort. |
| Confidence score: |
0.7408 |