circRNA basic information
circBase ID: hsa_circ_0001257
Name: hsa_circ_PLXNB2
Synonym: circPLXNB2
Host Gene: hsa-miR-654-3p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human AML cell lines (HL-60, Kasumi-1, 293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: hsa-miR-654-3p
Biological function: Knockdown of circPLXNB2 affected the proliferation, apoptosis and cell cycle distribution of AML cells
Molecular mechanism: circPLXNB2/hsa-miR-654-3p/CCND1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

In conclusion, circPLXNB2 was highly expressed in AML patients and cells and modulated tumor progression by regulating the circPLXNB2/miR-654-3p/CCND1 axis, suggested that circPLXNB2 might be a new therapeutic target for AML treatment.
Other information
Title:

CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.

Journal: Hematology
Published: 2023/6/5
PubMed ID: 37272581