| Expression pattern: |
UP |
| Associated gene: |
cyclin-dependent kinase 4 expression (CDK4), pyruvate kinase isozymes M2, Wnt/beta signaling pathway |
| Associated microRNA: |
miR-486 |
| Biological function: |
Associated with tumor progression and poorer overall survival in HCC; suggested to promote proliferation and invasion and inhibit apoptosis. |
| Molecular mechanism: |
Suggested ceRNA-like mechanism via sponging miR-486 to regulate CDK4; suggested involvement in glycolysis via pyruvate kinase isozymes M2; suggested activation of Wnt/beta signaling. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); Wnt/beta-catenin (promotes); stemness (promotes); chemoresistance (other); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
Elevated in tumor vs adjacent tissue and shows excellent diagnostic value (AUC 0.913); high expression correlates with shorter OS and is an independent predictor for poorer OS. |
| Description: |
Circ_0016788 is up-regulated in resected HCC tumor tissues and can discriminate tumor from adjacent tissue. High tumor circ_0016788 expression is associated with more aggressive clinicopathological features and independently predicts shorter overall survival. The paper discusses potential mechanisms including miR-486/CDK4 regulation, enhanced glycolysis, and Wnt/beta-catenin pathway activation. |
| Confidence score: |
0.5918 |