| Expression pattern: |
UP |
| Associated gene: |
IL-6, TNF-alpha, GLU, GHb |
| Associated microRNA: |
- |
| Biological function: |
potential diagnostic biomarker for T2DM; associated with hyperglycemia and inflammatory status (positively correlated with GLU, GHb, IL-6, TNF-alpha) |
| Molecular mechanism: |
- |
| Biological pathway or process: |
inflammation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
AUC for diagnosing T2DM vs controls: 0.9255 (95% CI = 0.8909-0.9601) |
| Description: |
In serum from T2DM patients, has_circ_CCNB1 is up-regulated and shows diagnostic value by ROC analysis. Its levels positively correlate with GLU, GHb, IL-6 and TNF-alpha, linking it to hyperglycemia-associated inflammation in T2DM. |
| Confidence score: |
0.4187 |