circRNA basic information
circBase ID: hsa_circ_0070934
Name: hsa_circ_LARP1B
Synonym: circ-0070934
Host Gene: LARP1B
Genomic location(hg19): chr4:128995614-129012667:+
Genomic location(hg38): chr4:128074459-128091512:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002529
MONDO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Disease DO ID:
 3151
Disease MeSH ID:
 -
Disease NCIt ID:
 C4819
Disease ICD11 ID:
 1448983042
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue
Cell lines:

A431; HSC-5; SCC13; SCL-1; HaCaT; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXB7, Ago2
Associated microRNA: miR-1236-3p
Biological function: Promotes proliferation and invasion; inhibits apoptosis in CSCC cells; promotes tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA/miRNA sponge to competitively bind miR-1236-3p and thereby upregulate HOXB7 expression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; TUNEL; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0070934 (circ-0070934) is up-regulated in CSCC cell lines and promotes proliferation and invasion while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1236-3p to upregulate HOXB7, enhancing CSCC tumor growth in a xenograft model.
Confidence score:

0.763
Other information
Title:

CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma.

Journal: International journal of oncology
Published: 2020
PubMed ID: 32626939
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -