| Expression pattern: |
UP |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-519a |
| Biological function: |
Promotes trophoblast proliferation and invasion and inhibits apoptosis. |
| Molecular mechanism: |
Acts as an upstream regulator of the miR-519a/PTEN signaling axis, restricting miR-519a and increasing PTEN. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
The circ-SETD2/miR-519a/PTEN axis is highlighted as a predictive potential target for fetal macrosomia pathogenesis. |
| Description: |
circ-SETD2 is up-regulated in placentas from fetal macrosomia cases and promotes trophoblast proliferation and invasion while reducing apoptosis. Mechanistically, it functions upstream of the miR-519a/PTEN axis by binding/restricting miR-519a, leading to increased PTEN expression. |
| Confidence score: |
0.6815 |