| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with favorable prognosis (longer PFS) when highly expressed. |
| Molecular mechanism: |
May enhance transcription of its parental gene TEP1 (discussion-level explanation). |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circ_0031113 expression was associated with a long PFS; circ_0031113 expression was increased in CR versus NR and associated with treatment response. |
| Description: |
circ_0031113 is upregulated in CR versus NR MM cases and is associated with better progression-free survival when highly expressed. The paper discusses a potential circ_0031113-TEP1 (host gene) relationship as a possible explanation for its favorable association. |
| Confidence score: |
0.5963 |